Drogas e medicamentos investigados para o tratamento do COVID-19 / Drugs and medicines investigated for the treatment of COVID-19

Objetivo: determinar drogas e medicamentos sugeridos para o tratamento do covid-19. Métodos: nesta pesquisa, foram utilizados os estudos que estavam definidos como ainda não recrutando e em fase de recrutamento, disponíveis no site Clinical Trials, em que foram inseridos os meios de intervenção, por meio de drogas e medicamentos. Resultados: com os filtros aplicados, os estudos em que ainda não estavam recrutando somaram um total de 131, e nos estudos que estavam em fase de recrutamento, existiam 126 análises. Conclusão: de acordo com a busca ativa, tanto nos estudos ainda não recrutando, quanto nos que estavam em recrutamento, a hidroxicloroquina é o medicamento que está sendo mais investigado.

Objective: to determine suggested drugs and medications for the treatment of covid-19. Methods: in this research, studies that were defined as not yet recruiting and in the recruitment phase were used, available on the Clinical Trials website, in which the means of intervention were inserted, using drugs and medications. Results: with the filters applied, the studies in which they were not yet recruiting totaled 131, and in the studies that were in the recruitment phase, there were 126 analyzes. Conclusion: according to the active search, both in studies not yet recruiting, and in those that were being recruited, hydroxychloroquine is the drug that is being investigated the most.

Influence of infiltrant application time on the reduction of opaqueness of proximal enamel caries

Introduction: Infiltrant resins were developed to hamper carious lesion progression and mask the whitish appearance of first evidence of caries. Objective: This study aimed at testing the hypothesis that a long application time of resin infiltrant in proximal enamel caries improves esthetic outcome compared to the commercially recommended time. Materials and Methods: Twenty teeth with uncavitated inactive proximal white enamel caries lesions (selected by two calibrated examiners; inter-examiner κ = 0.87) were divided into two groups (experimental and control group; n = 10) that agreed regarding lesion surface area. Lesions were infiltrated following the protocol recommended by the manufacturer (two applications, 3 min application first and another 1 min application later; control) and by the protocol tested in this study (one application of 30 min; experimental). Enamel opaqueness (esthetic outcome) was measured by a calibrated examiner (intra-class coefficient of 0.9) before and after infiltration using fluorescence microscopy. Results: Reduction of enamel opaqueness was significantly higher in the experimental group (40.0% ± 18.5%) than in the control group (18.6% ± 14.9%) (P = 0.0105, one-tailed t-test; Hedge's g of 1.28, 95% confidence interval of 0.43/2.13, and power of 86%). Conclusions: It can be concluded that the application time of 30 min provides a greater reduction in opaqueness of proximal enamel lesion compared to the application time recommended by the manufacturer. The high effect size could stimulate patients to comply with the treatment time.

A subjetividade do diagnóstico em Endodontia - relato de caso / The subjectivity of diagnosis in Endodontics - case report

Na Endodontia, em algumas situações, o diagnóstico é bastante subjetivo. Apesar dos fenômenos necróticos e degenerativos estarem presentes na necrose parcial pulpar, ainda podem ser observados filetes nervosos em algumas partes do tecido pulpar. Embora seja necessário o acompanhamento da vitalidade pulpar dos dentes submetidos ao tratamento ortodôntico, deve-se considerar a subjetividade do teste de vitalidade e o diagnóstico só será concluído quando do acesso a câmara pulpar. O objetivo deste estudo é relatar um caso de necrose pulpar parcial ocasionada por uma cárie profunda associada ao emprego de forças excessivas durante o tratamento ortodôntico.

In some situations diagnosis in Endodontic is a very subjective procedure. Despite the presence of necrosis and degenerative phenomena are present in partial pulp necrosis, nerve fibers can still be observed in some parts of the pulp tissue. While it is necessary to monitor the pulp vitality of the teeth subjected to orthodontic treatment, one should take into account the subjectivity of the vitality test and the diagnosis must be completed only when the pulp chamber is opened. The objective of this study was to report a case of partial pulp necrosis caused by deep tooth decay associated to excessive force during orthodontic treatment.